1  Cover

      2  Preface

      3  Acknowledgments

      4  About the Authors

      5  Key of Repetitive Elements

      6  1 Infections of Populations: History and Epidemiology Introduction to Viral Pathogenesis A Brief History of Viral Pathogenesis Viral Epidemics in History Epidemiology Parameters That Govern the Ability of a Virus to Infect a Population Perspectives References

      7  2 Barriers to Infection Introduction An Overview of Infection and Immunity Successful Infections Must Modulate or Bypass Host Defenses Viral Tropism Spread throughout the Host Organ Invasion Shedding of Virus Particles Perspectives References

      8  3 The Early Host Response: Cell Autonomous and Innate Immunity Introduction The First Critical Moments: How Do Individual Cells Detect a Virus Infection? Cell-Intrinsic Defenses Secreted Mediators of the Innate Immune Response The Innate Immune Response Perspectives References

      9  4 Adaptive Immunity and Establishment of Memory Introduction Attributes of the Host Response Lymphocyte Development, Diversity, and Activation Events at the Site of Infection Set the Stage for the Adaptive Response Antigen Processing and Presentation The CTL (Cell-Mediated) Response The Humoral (Antibody) Response Immunological Memory Perspectives References

      10  5 Patterns and Pathogenesis Introduction Animal Models of Human Diseases Patterns of Infection Viral Virulence Pathogenesis Perspectives References

      11  6 Cellular Transformation and Oncogenesis Introduction Oncogenic Viruses Activation of Cellular Signal Transduction Pathways by Viral Transforming Proteins Disruption of Cell Cycle Control Pathways by Viral Transforming Proteins Transformed Cells Increase in Size and Survive Tumorigenesis Requires Additional Changes in the Properties of Transformed Cells Other Mechanisms of Transformation and Oncogenesis by Human Tumor Viruses Perspectives References

      12  7 Vaccines Introduction The Origins of Vaccination Vaccine Basics The Science and Art of Making Vaccines Vaccine Technology: Delivery and Improving Antigenicity The Ongoing Quest for an AIDS Vaccine Perspectives References

      13  8 Antiviral Drugs