1  Cover

      2  Title Page

      3  Copyright Page

      4  Dedication

      5  Preface Bibliography

      6  Acknowledgments

      7  About the Authors

      8  1 Introduction Bibliography

      9  2 Common Musculoskeletal Disorders Overview Burden of MSDs Common Musculoskeletal Disorders Commonalities Among MSDs Bibliography

      10  3 Structure and Function of the Musculoskeletal System A Systems View of the Musculoskeletal System Connective Tissues: General Overview Skeletal (Striated) Muscle Tendon Cartilage Bone Ligament Joints Summary Bibliography

      11  4 Structure and Function of the Nervous System and Its Relation to Pain Overview A Systems View of the Nervous System An Introduction to Cellular Components of the Nervous System Structure and Function of the Peripheral Nervous System Interactions of Peripheral Nerves with the Musculoskeletal System Central Nervous System Components that Interact with the Musculoskeletal System Pain Summary Bibliography

      12  5 Fundamental Biomechanics Concepts Introduction Newton's Laws Biomechanical Modeling Summary Bibliography

      13  6 Material Properties of Musculoskeletal and Peripheral Nerve Tissues Overview Fundamentals of Materials Science Material Deformation of Musculoskeletal Tissues General Characteristics of Deformation in Musculoskeletal Tissues Material Properties of Musculoskeletal Components Material Properties of Peripheral Nerves Summary Bibliography

      14  7 Fatigue Failure of Musculoskeletal Tissues Introduction Ex Vivo Studies of Fatigue Failure in Musculoskeletal Tissues In Vivo Studies of Fatigue Failure Epidemiological Data Summary Bibliography

      15  8 MSDs as a Fatigue Failure Process Introduction Prior Models and Approaches Upper Extremity Risk Assessment Tools Summary of Prior Models Considering MSD Risk Factors from the Fatigue Failure Perspective Benefits of the Fatigue Failure Model Other Potential Applications of Fatigue Failure Summary Bibliography

      16  9 Fundamentals of Fatigue Failure Analysis Introduction Fatigue Terminology Mechanisms of Fatigue Failure The Stress‐Life (S–N) Curve Plastic Strain Fatigue Life Estimation Methods Cumulative Damage and Residual Strength Models