Genetic Analysis of Complex Disease. Группа авторов

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Genetic Analysis of Complex Disease - Группа авторов


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       Allison Ashley Koch1 and Evadnie Rampersaud2

       1 Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA

       2 Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA

      Genetics is believed to contribute to the etiology of almost every human trait and condition. Even for infectious diseases that have been traditionally described as environmental, such as tuberculosis and HIV, genetic factors have been implicated either in the susceptibility to infection or in the severity of the condition (Bellamy 1998; Hill 1999; Bellamy et al. 2000; Gonzalez et al. 2001; Shields and Dell 2001). Understanding the role of genetics in disease etiology can allow development of successful therapies that improve the quality of life for affected individuals and their families. However, before embarking on expensive and labor‐intensive studies to identify the genetic factors involved in a particular condition, one should evaluate the evidence that genes contribute to that trait or condition.

      However, even in the presence of such complexities, there are methods available to evaluate whether or not genetics plays an important role in the disease etiology. Those methods are the primary topic of this chapter and should be explored prior to embarking on more elaborate analyses such as genome‐wide association analyses or linkage analyses. Importantly, before considering any analysis,


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