Poisonous Plants and Phytochemicals in Drug Discovery. Группа авторов

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Poisonous Plants and Phytochemicals in Drug Discovery - Группа авторов


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aid flow and continuity.

      Andrew G. Mtewa Andrew is a member of the American Chemical Society, the Phytochemical Society of Europe and the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers and an associate member of the Royal Society of Chemistry. He studied Education (Chemistry) for a Bachelor’s degree and Applied Chemistry (Natural Product Chemistry) for his MSc at Chancellor College, University of Malawi. For his PhD, he trained in Medicinal Chemistry, focusing on drug design, synthesis, and development at the University of Dundee, UK, under the Wellcome Centre for Anti‐Infectives Research training program, and in Pharmbiotechnology (Medicinal Chemistry) at Mbarara University of Science and Technology in Uganda. His current interest and the focus of his research group is in the designing, synthesis, and hit expansion of potential drugs against diseases that cause a heavy burden on developing countries. He is also interested in encouraging developing countries to be much more involved in medicinal chemistry and all preclinical aspects of the drug development pipeline beyond just extracts. He is a lead editor of another book on phytochemistry with Elsevier and carries out reviews for some journals, including BMC’s Systematic Reviews and Elsevier’s Tuberculosis. Andrew teaches Chemistry at the Malawi University of Science and Technology.

      G.M. Narasimha Rao G.M. Narasimha Rao is an Assistant Professor of Botany at Andhra University, India. He holds an MSc, MPhil, and PhD in Botany. He has worked on marine algae and mangroves, ecology, physiology, and chemical studies for many years and sits on the editorial board of Marine Science. He has vast teaching and research experience gained over many years and has published extensively in his field of research.

       Godwin Anywar

       Department of Plant Sciences, Microbiology & Biotechnology, College of Natural Sciences, Makerere University, Kampala, Uganda

      CONTENTS

      1  1.1 Introduction to Toxic Plants

      2  1.2 Poisonous Plants as Sources of Traditional and Modern Medicines

      3  1.3 Toxic Plants and Justice 1.3.1 Toxic Plants in Capital Punishment 1.3.2 Trial by Ordeal

      4  1.4 Toxic Plants in Poisoned Weapons 1.4.1 Arrow Poisons

      5  1.5 Plant Fishing Poisons/Piscicides/Ichthyotoxins

      6  1.6 Poisonous Plants as Food

      7  1.7 Poisonous Plants as Biopesticides

      8  1.8 Toxic Psychoactive Plants for Recreational and Religious Purposes

      9  1.9 Poisonous Plants in Warfare and Bioterrorism

      10  1.10 Poisonous Plants as Carcinogens and Teratogen

      11  1.11 Conclusion

      Numerous poisonous plants exist in our environment and have been the subject of great speculation, study, and concern. Poisonous plants have been used as food, medicines, agents for crime, means of dispensing justice, capital punishment, suicide, bioterrorism, fishing poisons, and for recreational and spiritual purposes as hallucinogens or psychoactive agents. Such plants can cause a wide range of adverse effects when ingested by animals or people, depending on the organ system affected [1, 2].

      This chapter looks at some notable examples of widely studied toxic plants but is by no means exhaustive. Even among the widely studied examples, there is incomplete toxicity information [6–8]. The chapter introduces the reader to numerous general aspects of toxic plants. Toxic plants are of great economic importance in the livestock industry but also pose a threat to the health of humans and domestic animals, which are often exposed to the same toxic plants because of a shared environment. Various toxic compounds from plants such as those used in arrow and dart poisons could prove valuable for drug discovery and research [9].


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