1  Cover

      2  Volume I Preface What’s New Principles Taught in Two Distinct, but Integrated Volumes Acknowledgments About the Authors Key of Repetitive Elements PART I: The Science of Virology 1 Foundations Luria’s Credo Viruses Defined Why We Study Viruses Virus Prehistory Discovery of Viruses The Defining Properties of Viruses Cataloging Animal Viruses A Common Strategy for Viral Propagation Perspectives References 2 The Infectious Cycle Introduction The Infectious Cycle Viral Pathogenesis Overcoming Host Defenses Cultivation of Viruses Assay of Viruses Viral Reproduction: the Burst Concept The One-Step Growth Cycle Global Analysis Single-Cell Virology Perspectives References PART II: Molecular Biology 3 Genomes and Genetics Introduction Genome Principles and the Baltimore System Structure and Complexity of Viral Genomes What Do Viral Genomes Look Like? Coding Strategies What Can Viral Sequences Tell Us? The “Big and Small” of Viral Genomes: Does Size Matter? The Origin of Viral Genomes Genetic Analysis of Viruses Perspectives References 4 Structure Introduction Building a Protective Coat Packaging the Nucleic Acid Genome Viruses with Envelopes Large Viruses with Multiple Structural Elements Other Components of Virions Mechanical Properties of Virus Particles Perspectives References 5 Attachment and Entry Introduction Attachment of Virus Particles to Cells Entry into Cells Intracellular Trafficking and Uncoating Import of Viral Genomes into the Nucleus Perspectives References 6 Synthesis of RNA from RNA Templates Introduction The Nature of the RNA Template The RNA Synthesis Machinery Mechanisms of RNA Synthesis Paradigms for Viral RNA Synthesis Origins of Diversity in RNA Virus Genomes Perspectives References 7 Synthesis of RNA from DNA Templates Introduction Transcription by RNA Polymerase II Transcription of Viral DNA Templates by the Cellular Machinery Alone Viral Proteins That Govern Transcription of DNA Templates Transcription