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rel="nofollow" href="#ulink_13d0d854-138b-5d20-aed1-f7fd1664f1bc">13.8 Radiation Grafting 13.9 Chemical Reactions 13.10 Solution Processing of Coatings 13.11 Biological Functionalization of Biomaterials 13.12 Concluding Remarks Problems References Further Reading

      9  Part IV: Degradation of Biomaterials in the Physiological Environment 14 Degradation of Metallic and Ceramic Biomaterials 14.1 Introduction 14.2 Corrosion of Metals Problems References Further Readings 15 Degradation of Polymeric Biomaterials 15.1 Introduction 15.2 Hydrolytic Degradation 15.3 Enzyme‐Catalyzed Hydrolysis 15.4 Oxidative Degradation 15.5 Other Types of Degradation 15.6 Concluding Remarks Problems References Further Readings

      10  Part V: Biocompatibility Phenomena 16 Biocompatibility Fundamentals 16.1 Introduction 16.2 Biocompatibility Phenomena with Implanted Devices 16.3 Protein and Cell Interactions with Biomaterial Surfaces 16.4 Cells and Organelles 16.5 Extracellular Matrix and Tissues 16.6 Plasma and Blood Cells 16.7 Platelet Adhesion to Biomaterial Surfaces 16.8 Platelets and the Coagulation Process 16.9 Cell Types and Their Roles in Biocompatibility Phenomena 16.10 Concluding Remarks Problems References Further Reading 17 Mechanical Factors in Biocompatibility Phenomena 17.1 Introduction 17.2 Stages and Mechanisms of Mechanotransduction 17.3 Mechanical Stress‐Induced Biocompatibility Phenomena 17.4 Outcomes of Transduction of Extracellular Stresses and Responses 17.5 Concluding Remarks Problems References Further Reading 18 Inflammatory Reactions to Biomaterials 18.1 Introduction 18.2 Implant Interaction with Plasma Proteins 18.3 Formation of Provisional Matrix 18.4 Acute Inflammation and Neutrophils 18.5 Chronic Inflammation and Macrophages 18.6 Granulation Tissue 18.7 Foreign Body Response 18.8 Fibrosis and Fibrous Encapsulation 18.9 Resolution of Inflammation 18.10 Inflammation and Biocompatibility 18.11 Concluding Remarks Problems References Further Reading 19 Immune Responses to Biomaterials 19.1 Introduction 19.2 Adaptive Immune System 19.3 The Complement System 19.4 Adaptive Immune Responses to Biomaterials 19.5 Designing Biomaterials to Modulate Immune Responses 19.6 Concluding Remarks Problems References 20 Implant‐Associated Infections 20.1 Introduction 20.2 Bacteria Associated with Implant Infections 20.3 Biofilms and their Characteristics 20.4 Sequence of Biofilm Formation on Implant Surfaces 20.5 Effect of Biomaterial Characteristics on Bacterial Adhesion 20.6 Biofilm Shielding of Infection from Host Defenses

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