Real World Health Care Data Analysis. Uwe Siebert

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Real World Health Care Data Analysis - Uwe Siebert


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total scoreNMiss00Mean13.0713.14Std6.046.02BPI Pain scoreNMiss00Mean5.515.54Std1.741.76BPI Interference scoreNMiss00Mean6.086.00Std2.172.15
realtype
realsimulated
Visit15751000
2N
Opioids use3.112.70
ColPctN
NoColPctN71.0570.10
YesColPctN25.8427.20
Satisfaction with Overall Fibro Treatment5.654.80
.ColPctN
1ColPctN16.1316.60
2ColPctN25.3326.50
3ColPctN27.3028.10
4ColPctN18.4817.00
5ColPctN7.117.00
Satisfaction with Prescribed Medication6.296.10
.ColPctN
1ColPctN11.3710.50
2ColPctN24.3824.00
3ColPctN30.4831.90
4ColPctN19.5620.50
5ColPctN7.947.00
PHQ8 total scoreNMiss5022
Mean11.8811.86
Std5.925.75
BPI Pain scoreNMiss6247
Mean5.335.34
Std1.921.94
BPI Interference scoreNMiss4936
Mean5.545.50
Std2.362.40
realtype
realsimulated
Visit1483950
3N
Opioids use4.995.05
ColPctN
NoColPctN68.3765.37
YesColPctN26.6429.58
Satisfaction with Overall Fibro Treatment8.506.63
.ColPctN
1ColPctN16.6616.74
2ColPctN25.6225.47
3ColPctN26.5026.84
4ColPctN16.4516.84
5ColPctN6.277.47
Satisfaction with Prescribed Medication8.029.47
.ColPctN
1ColPctN12.7413.47
2ColPctN23.4021.58
3ColPctN31.6331.89
4ColPctN17.8716.32
5ColPctN6.347.26
PHQ8 total scoreNMiss7444
Mean12.1812.31
Std6.226.30
BPI Pain scoreNMiss9552
Mean5.235.13
Std1.971.98
BPI Interference scoreNMiss7451
Mean5.475.64
Std2.432.36
realtype
realsimulated
Visit1378888
4N
Opioids use3.854.62
ColPctN
NoColPctN67.8566.10
YesColPctN28.3029.28
Satisfaction with Overall Fibro Treatment8.139.91
.ColPctN
1ColPctN18.8716.55
2ColPctN25.4725.23
3ColPctN27.0728.38
4ColPctN15.4615.20
5ColPctN5.014.73
Satisfaction with Prescribed Medication7.846.98
.ColPctN
1ColPctN13.1314.41
2ColPctN26.8525.34
3ColPctN31.2029.95
4ColPctN15.8917.23
5ColPctN5.086.08
PHQ8 total scoreNMiss5634
Mean11.4811.65
Std6.066.12
BPI Pain scoreNMiss7248
Mean5.205.15
Std2.002.05
BPI Interference scoreNMiss5340
Mean5.395.59
Std2.472.47
realtype
realsimulated
Visit1189773
5N
Opioids use0.250.13
ColPctN
NoColPctN68.2167.53
YesColPctN31.5432.34
Satisfaction with Overall Fibro Treatment3.033.36
.ColPctN
1ColPctN16.8214.62
2ColPctN27.7527.30
3ColPctN28.8530.53
4ColPctN16.0616.04
5ColPctN7.498.15
Satisfaction with Prescribed Medication4.794.79
.ColPctN
1ColPctN13.4612.42
2ColPctN27.3325.49
3ColPctN33.5635.58
4ColPctN14.8915.14
5ColPctN5.976.60
PHQ8 total scoreNMiss00
Mean11.9111.70
Std6.266.27
BPI Pain scoreNMiss1811
Mean5.165.10
Std2.062.08
BPI Interference scoreNMiss10
Mean5.315.34
Std2.472.53

      Figure 3.1 presents the full distribution of a continuous variable (BPI Pain score) for the real and simulated data by visit.

      Figure 3.1: Histograms of BPI Pain Scores by Visit for Actual and Simulated REFLECTIONS Data

      Figures 3.2 and 3.3 present the correlation matrices for the actual and simulated data sets. The correlation patterns are well preserved in the simulated data though the strength of the associations is slightly less. Again, the Iman-Conover method approximates the desired rank correlations.

      Figure 3.2: Rank-correlation Matrix for Actual REFLECTIONS Data

      Figure 3.3: Rank-correlation Matrix for Simulated REFLECTIONS Data

      In addition to the visit-wise simulated REFLECTIONS data described previously (used for Chapters 11 and 12), we created a one observation per patient version of the data set with variables as shown in Table 3.5. This is referred to as the REFL data set and is used in Chapters 4–6 and 8–10.

      Table 3.5: REFL Data Set Variables

Variable NameVariable Label
SubjIDSubject Number
CohortCohort
GenderGender
AgeAge in years
BMI_BBMI at Baseline
RaceRace
InsuranceInsurance
DrSpecialtyDoctor Specialty
ExerciseExercise
InptHospInpatient hospitalization in last 12 months
MissWorkOthOther
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