Welcome to the Genome. Michael Yudell
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2 The Building Blocks of Gene Sequencing
In the 1940s the Nobel Prize‐winning physicist Erwin Schrodinger inspired a generation of scientists to study genes. Known primarily for his work in quantum mechanics, Schrodinger spent World War II in exile in Dublin, where in February 1943 he gave a pioneering series of lectures at Trinity College on the importance of understanding the physical laws that govern heredity. These groundbreaking talks, published a year later as a slim volume entitled What is Life?, anticipated the importance of DNA just as scientists began to establish the nature of what Schrodinger called “the most essential part of a living cell—the chromosome fibre.” (1) With no formal training in the biological sciences, Schrodinger came to genetics with what he called “a naïve physicist’s ideas about organisms.” (2) Despite this limitation, by combining a physicist’s sense of the need for order in the natural world with a sophisticated