Arthritis For Dummies. Barry Fox
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And although gout typically affects the big toe joint, pseudogout more often targets the knee.
The disease itself may be acute or chronic. Acute attacks are likely to strike suddenly, settle in, and last for several days or even weeks. (Fortunately, they are usually not as painful as acute attacks of “true” gout.) The chronic form of pseudogout produces attacks that last longer, typically targets more than one joint at a time and, with time, severely damages those joints.
The causes of pseudogout are unknown. Surgery, a hormonal imbalance, or a metabolic upset may touch it off. Sometimes it strikes in conjunction with other diseases or conditions, such as low blood levels of magnesium or excessive blood levels of iron or calcium. Pseudogout strikes men and women at about the same rate and prefers older folks, especially those over the age of 60. Trauma to a joint will also increase the risk of developing pseudogout in that joint.
Diagnosing and treating pseudogout
Because pseudogout can masquerade as gout, rheumatoid arthritis, or another ailment, diagnosis is usually made by inspecting fluid taken from the affected joint. If you have pseudogout, your fluid will contain calcium pyrophosphate dihydrate crystals. (These crystals can also be picked up on X-rays.)
Unfortunately, there’s no way to cure the disease completely and no method for removing the offending crystals from the joints. Instead, doctors will try to relieve the symptoms, typically by prescribing NSAIDs or the gout drug, colchicine, to reduce the pain and inflammation. In difficult cases, steroids such as prednisone may be needed to get the inflammation under control. Your doctor may also “tap” the joint and draw out the excess fluid to relieve the pain. Any of these treatments can bring relief during attacks but they can’t prevent joint damage. Unlike gout, there is no curative long-term treatment for pseudogout. But, fortunately, most sufferers will do well if their pain and inflammation are kept under control by medication.
Understanding Juvenile Idiopathic Arthritis
Arthritis is bad for everyone, but it seems worse when it strikes children. Juvenile idiopathic arthritis or JIA (formerly called juvenile rheumatoid arthritis or JRA) is a broad term for childhood arthritis diseases that appear before the age of 17 and are characterized by joint inflammation that lasts more than six weeks. Nearly 300,000 children in the U.S. are affected by arthritis or other rheumatic conditions; more children than are currently affected by cystic fibrosis, sickle cell anemia, and muscular dystrophy combined.
Summarizing the symptoms
There are seven kinds of JIA that can be differentiated by their symptoms:
Enthesitis-related arthritis (ERA): ERA causes pain and swelling in the joints and the points where tendons and ligaments attach to the bone. The hips, knees and feet are the most likely sites of this form of JIA, although the back and the sacroiliac joint (the triangular bone between the lumbar spine and the tailbone) can also be affected, usually later in the disease process. ERA occurs most often in boys older than age 10. The presence of the HLA-B27 gene and eye inflammations called uveitis or iridocyclitis are commonly seen with ERA. These forms of eye inflammation can cause irreversible eye damage, so it’s important for children with JIA to be routinely screened by an ophthalmologist.
Oligoarthritis: Around half of all children with JIA have oligoarthritis, which usually involves less than five joints, strikes in the knees and other large joints, and may only strike one of a pair of joints (one knee rather than both, and so on). In 20 to 30 percent of cases, oligoarthritis can trigger the eye inflammations uveitis or iridocyclitis. Fortunately, many children outgrow oligoarthritis, although eye problems can continue into adulthood.
Polyarthritis, rheumatoid factor-negative or -positive: Polyarthritis strikes some 40 percent of those with JIA and attacks five or more joints during the first six months of the disease. It usually appears in children younger than 5 and settles in the fingers and other small joints, although the large joints are not immune. The disease is usually symmetrical, which means it attacks the fingers on both hands, rather than just one. There may also be a fever and rheumatoid nodules. Polyarthritis is further divided into those that test positive for rheumatoid factor (RF) and those who do not. Of all the types of JIA,polyarthritis with a positive RF is the one that is the most like adult RA.
Psoriatic arthritis: This form of arthritis is much like the adult form of the same disease, both of which are combinations of psoriasis and arthritis. Usually involving the knees and/or the small joints of the hands and feet, psoriatic arthritis starts with a few joints then spreads to others. In 50 percent of sufferers, severe inflammation of the finger joints and toe joints can make the digits look like sausages.
Systemic JIA: The systemic form of JIA affects the entire body, causing trouble wherever it settles. The least common form of the disease, systemic JIA may produce fever, pale red spots on various parts of the body, anemia, swollen lymph nodes, inflammation of the linings of the lungs and heart, joint swelling, pain and stiffness, and other problems.
Undifferentiated arthritis: This is the catchall category for various kinds of arthritis that don’t fit into any of the other categories, or belong to more than one category.
Diagnosing and treating JIA
To be considered JIA, the disease must produce joint inflammation and stiffness in at least one joint for at least six weeks in a person under the age of 17.
JIA is similar to adult rheumatoid arthritis, with a few key differences:
Many children with JIA outgrow the problem, while most adults with RA don’t.
JIA may affect bone development and growth in children, causing slow, rapid, or uneven growth in the afflicted joints.
Less than 50 percent of children with JIA test positive for rheumatoid arthritis factor, compared to 70 or 80 percent of adults.
Doctors diagnose and treat JIA in much the same way they do the adult version. But in addition to the medical treatment, children with JIA need special emotional and social support.
Investigating Infectious Arthritis
Infectious arthritis is caused by viruses, bacteria, or fungi that enter the body and settle into one or more joints. Depending upon which germs have invaded, they joint(s) they inhabit, the strength of the immune system, and the speed and accuracy of the treatment, a bout with infectious arthritis may be brief and relatively easy to take, or serious and painful.