To Catch a Virus. John Booss

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To Catch a Virus - John Booss


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Wilkinson, L. 2002. History, p. 1–22. In A. C. Jackson and W. H. Wunner (ed.), Rabies. Academic Press, Amsterdam, The Netherlands.

      Filling the Churchyard with Corpses: Smallpox and the Immune Response

      In the final analysis, only an antibody response in the host constitutes definitive evidence of infection with a specific virus.

      Introduction

      The emergence of immunological concepts in the latter half of the 19th century and at the start of the 20th century and the development of assays to measure antibodies against invading pathogens transformed therapeutic approaches and management of infectious diseases. Like virology, the science of immunology developed in the wake of advances in bacteriology. Crucial to the development of immunology was the understanding of mechanisms of defense. These were first understood in the protection against reinfection for certain well-recognized diseases such as smallpox.

      Protection: the Case of Smallpox


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